Job description
** About Integrated Biosciences **
At Integrated, we are ** ** focused on ** ** advancing small molecule therapeutics for age-related diseases. We have built a first-of-its-kind discovery platform at the intersection of phenotypic models of aging, chemistry, and AI. Backed by top-tier VCs, and with recent publications in * Cell * (2025), * Nature * (2024), * Nature Aging * (2023), and * Nature Protocols * (2025), we’re rapidly expanding our senior scientific team to accelerate our growing pipeline.
** About the Role **
We’re seeking a driven and experienced and scientifically rigorous Director of In Vivo Pharmacology to join us at a pivotal moment. In this leadership role, you’ll lead a team to conduct animal studies that drive our drug discovery pipeline forward. You will serve as the in-house expert on animal models, in vivo study design, and translational pharmacology.
You’ll play a key role in shaping our scientific strategy and driving milestone achievements across our pipeline.
If you’re someone who combines deep R&D rigor with a mindset that challenges convention, and you’re passionate about advancing breakthrough therapeutics, we want to hear from you.
** You will **
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Design, execute, and interpret in vivo pharmacology studies to support lead optimization, candidate selection, and IND-enabling activities across multiple small molecule programs.
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Develop, validate, and implement disease-relevant animal models (efficacy, mechanistic, and tolerability) in collaboration with internal and external teams.
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Define translational pharmacology strategies, including PK/PD modeling, biomarker selection, and dose prediction frameworks to support clinical translation.
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Partner with DMPK, medicinal chemistry, and biology teams to integrate in vitro and in vivo data into holistic SAR and candidate progression decisions.
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Oversee vivarium staffing, scheduling, and day-to-day operations in collaboration with animal care personnel; serve as primary scientific liaison to the IACUC committee.
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Communicate study results clearly to internal stakeholders through high-quality data packages, presentations, and written reports.
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Contribute to IND filings, regulatory submissions, and due diligence activities as needed.
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Build and mentor a growing in vivo pharmacology team; contribute to a culture of scientific excellence and collaboration.
** You’re a good fit if you have (required) **
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PhD in pharmacology, physiology, cancer biology, or a related field, with 8+ years of relevant industry experience.
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Deep expertise in small molecule in vivo pharmacology, including broad hands-on proficiency with rodent models of disease (oncology, metabolic, inflammation, or other therapeutic areas).
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Strong understanding of PK/PD principles and experience integrating pharmacokinetic and pharmacodynamic data to guide compound optimization.
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Comfort operating at both strategic and bench levels.
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Demonstrated ability to lead, mentor, and build effective scientific teams.
** Bonus Points For **
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Experience in cardiometabolic disease and/or aging biology
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Experience in toxicology
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Comfort with cutting-edge data analysis, large data sets, p and p ioneering AI approaches
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Startup-ready mindset: agile, proactive, and comfortable with ambiguity in a fast-paced environment
** Location & Logistics **
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Visa sponsorship available where applicable. We’ll work with you to make it happen.
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This role will be located at Redwood LIFE in Redwood City, CA, a modern and stunning life sciences complex in the Bay Area.
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Start date: immediate.
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We are an equal-opportunity employer and strongly encourage applications from individuals of diverse backgrounds, experiences, and perspectives.
** Compensation & benefits **
We offer a highly competitive salary, substantial equity, and comprehensive benefits, including medical and dental coverage, company-provided lunch, 401k match, and others.