Researcher II

Development of Glyco-engineered CHO cells for improving protein drug quality and safety This project will fund a contracted professional with MS or PhD in biochemistry, glycobiology, molecular biology, chemistry, pharmaceutics, or related field. For a candidate possessing an MS, at least two years of relevant experience is required in biopharmaceutical manufacturing, quality analytics, biotechnology research and development or other relevant areas

• Scope of Work:
• Establish, and fully-characterize genetically modified (engineered) cell lines;
• Purify the therapeutic proteins produced by engineered CHO cell lines;
• Analyze the glycans of therapeutic proteins endogenous glycoproteins and other glycoconjugates with mass spectrometry (MS), such as MALDI-TOF, LC-MS, and Ion-mobility spectrometry– MS (IMS-MS or IMS), (U)HPLC and other state-of-the-art technologies;
• Establish new analytical methods to release and analyze O-glycans from glycoproteins;
• Establish new analytical methods and procedures for testing the quality of protein drugs;
• Summarize and prepare data reports using Microsoft Word or Power Point;
• Have weekly progress meetings to update the PI and report any pitfalls or shortcomings;
• Write manuscripts and/or technique reports for publications or white papers on the project Requirements Development of Glyco-engineered CHO cells for improving protein drug quality and safety This project will fund a contracted professional with MS or PhD in biochemistry, glycobiology, molecular biology, chemistry, pharmaceutics, or related field. For a candidate possessing an MS, at least two years of relevant experience is required in biopharmaceutical manufacturing, quality analytics, biotechnology research and development or other relevant areas Benefits PPO/HMO Health Plan (includes medical, dental, and vision) 401K Retirement Plan Paid Time Off (PTO)