Job description
Job description At Orakl Oncology, we are accelerating the development of oncology treatments. Today, fewer than 5% of new cancer drugs succeed in clinical trials. Clearly, new methods are needed. We combine cutting-edge biology and AI to build the next generation of insight platforms with the world’s largest cohort of patient tumor avatars.
These avatars fuel our AI-powered predictive engine, helping to anticipate clinical trial outcomes, validate therapies, and uncover new drug candidates. Our mission is simple yet ambitious: to bring more effective treatments to patients who need them - and to make drug development smarter, faster, and more personalized.
We collaborate with top hospitals, research institutes, and pharmaceutical companies worldwide. Backed by leading investors, we are a fast-growing, mission-driven startup at the intersection of science and technology. We are looking for a passionate and dynamic hands-on scientist to build Orakl's CRISPR and functional genomics capabilities from the ground up.
Reporting directly to the Principal Scientist, Gizem, you'll design and run gene-perturbation and drug screens in our patient-derived tumor organoids, generating the high-quality biological data that powers our AI predictive engine. Preferred Experience MUST HAVE
- PhD in molecular biology, cancer biology, biotechnology, or related field, ~1–5 years industry experience would be a plus.
- Proven proficiency with CRISPR gene editing in mammalian systems (ideally in organoids): gRNA design, MOI optimization, KO validation.
- Experience with both lentiviral-based and electroporation-based is preferred.
- Hands-on expertise in organoid culture.
- Knowledge of molecular biology techniques (RT PCR, qPCR/ddPCR, Western Blot, DNA and RNA isolation etc.) and flow cytometry/FACS.
- Exceptional wet-lab fundamentals: sterile technique, routine culture, molecular biology, cloning, assay development, QC.
- Demonstrated ability to independently plan, prioritize, and execute complex experimental pipelines with high quality and reproducibility.
- Strong analytical, quantitative data interpretation, and clear documentation/reporting skills.
NICE TO HAVE
- Experience with pooled/arrayed CRISPR screens or other functional genomics approaches.
- Experience with drug-response profiling in organoids (dose–response, time-course, combination assays) and high-throughput screening.
- Knowledge of programming e.g. Python
- Previous responsibility for managing CROs or academic collaborations.
- Experience mentoring junior scientists, lab technicians and/or establishing lab standards.
- Prior involvement in early-stage drug discovery or cross-functional oncology research. What will you find at Orakl
- Mission: Work in a cutting-edge environment, on the bleeding edge of cancer research.
- Growth opportunities: we’re rapidly expanding the scope of our work and you will be offered multiple opportunities to grow with it!
- Impact: you’re going to be participating in a fast-growing, multi-faceted project with multiple opportunities to shape it according to your interests.
- More about Orakl on our Welcome to the Jungle page https://www.welcometothejungle.com/fr/companies/orakl-oncology and on our website https://www.orakl-oncology.com Recruitment steps
- Introduction call (20min) – An initial discussion to better understand your background, experiences, and motivations.
- Technical Interview (45min) – A deep dive into your technical skills and expertise relevant to the role.
- Case Interview (1h) – A case study or problem-solving exercise to assess your strategic thinking and analytical abilities. In-person when possible to meet the team.
- Reference calls - 2-3 references including at least a direct manager.
- Culture Fit Interview (45min) – A conversation with our team to ensure alignment with our company culture, values, and ways of working.