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Principal Enterprise Architect, Digital Solutions

McKesson

USA, TX, IrvingFull-time$187k – $312kPosted Oct 8, 2026

Job description

Mc. Kesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care. What you do at Mc.

Kesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you.

Role Summary

The Principal Enterprise Architect, Digital Solutions is a senior leader responsible for defining and advancing the enterprise digital architecture strategy that enables scalable, secure, and innovative digital solutions for US Oncology Practices. This role partners closely with executive leaders, business stakeholders, clinical teams, and technology teams to translate Practice strategy into cohesive architectural direction.

Key Role Success Metrics Unified enterprise architecture blueprint established and regularly updated as needed. Multi-year digital roadmap delivered and socialized, with regular updates as needed. Architecture governance adopted across teams. Modernization and interoperability improvements realized.

Key Responsibilities

Define and evolve the enterprise digital architecture vision, principles, and roadmaps aligned with business objectives. Provide architectural leadership for major digital initiatives, platform strategies, and transformation programs. Advise executives and senior leaders on technology trends, risks, and long-term architectural implications.

Ensure digital solutions are secure, scalable, interoperable, and compliant with enterprise and regulatory standards. Establish and maintain reference architectures, patterns, and governance. Influence and mentor architects and technical leaders through thought leadership. Role Characteristics Enterprise-wide scope with significant strategic and technical influence.

Operates effectively in highly complex and ambiguous environments. Combines deep technical expertise with business and strategic acumen. Recognized authority for digital architecture and cross-domain design decisions. Required Qualifications 15+ years in enterprise architecture or engineering leadership roles. Expertise in cloud modernization, multi-tenant platforms, and large-scale system design.

Strong integration architecture background with APIs and interoperability standards. Experience with data platforms, semantic layers, analytics, and governed access models. Familiarity with clinical systems and oncology digital workflows preferred.

Preferred Qualifications

Experience in oncology, clinical operations, or life sciences. Certifications: TOGAF, AWS/Azure Architect. Experience applying AI/ML to enterprise digital solutions, defining AI platform standards, and familiarity with cloud‑native AI services Working Conditions Environment (Office, warehouse, etc.) – Normal office environment Physical Requirements (Lifting, standing, etc.)

– Normal office environment requirements Travel Up to 25% travel required We are proud to offer a competitive compensation package at Mc. Kesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets.

The pay range shown below is aligned with Mc. Kesson's pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at Mc. Kesson, please click here.

Our Base Pay Range for this position $187,400 - $312,400 Mc. Kesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by Mc. Kesson are using Mc. Kesson’s (or affiliated entities, like Cover. MyMeds or Rx. Crossroads) name in fraudulent emails, job postings or social media messages.

In light of these scams, please bear the following in mind: Mc. Kesson Talent Advisors will never solicit money or credit card information in connection with a Mc. Kesson job application. Mc. Kesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail.

Note that Mc. Kesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates. Mc. Kesson job postings are posted on our career site: careers.mckesson.com . Mc. Kesson is an Equal Opportunity Employer Mc. Kesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category.

For additional information on Mc. Kesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page. Mc. Kesson is committed to being an Equal Employment Opportunity Employer and offers opportunities to all job seekers including job seekers with disabilities. If you need a reasonable accommodation to assist with your job search or application for employment, please contact us by sending an email to (United States) Disability_Accommodation@Mc.

Kesson.com or (Canada) Accessibility@mckesson.ca . Resumes or CVs submitted to this email box will not be accepted. Join us at Mc. Kesson!

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