PHYSICAL PHARMACEUTICA LLC jobs and careers

About PHYSICAL PHARMACEUTICA LLC

Physical Pharmaceutica (PhysPharm) provides advanced in vitro testing, scientific consulting, and modeling to support drug formulation, delivery, and AI innovation. PhysPharm is led by Dr. Robert A. Bellantone, a recognized expert who is a physicist, pharmacist, and Professor Emeritus of Pharmaceutical Science. We deliver science, practical guidance, and proprietary technologies to identify and generate data to inform decisions from R&D through commercialization. Our Pulsatile Microdialysis (PMD) platform measures free (bioavailable) drug concentrations in situ and in real time to capture dynamic kinetic processes, including supersaturation decay, nucleation, redistribution, and carrier-mediated release, in media that simulate physiological conditions. Unlike conventional assays that report total or solubilized drug, PMD isolates the free drug, which drives absorption and pharmacologic effects. We work with • Formulation teams optimizing amorphous solid dispersions (ASDs), micro- and nanoemulsions, nanoparticles, and complex delivery systems—including ophthalmics • AI companies and modelers seeking wet-lab data to tune and validate predictive outputs • R&D and regulatory leads requiring mechanistic insight to de-risk development or support IVIVC, PBPK, or FDA submissions Our approach integrates physical science and chemistry, biopharmaceutics, and mechanistic modeling to help clients design better experiments, extract meaningful parameters, and connect lab results to predictive models. Examples • A pharma company needs an IVRT method for ophthalmic emulsions. We developed the lab test and kinetic model to quantify drug distribution across emulsion phases. • An AI team models ASD dissolution but lacks real data to confirm supersaturation duration. We quantify the spring–parachute profile of free drug to support absorption prediction. • Modeling predicts pH-triggered release but investors want proof. We generate in vitro data in pH-shifted, protein-rich media.