Precision Medicine Lab (TTOM B.V.) jobs and careers

About Precision Medicine Lab (TTOM B.V.)

Precision Medicine Lab aims to create novel therapies for selected patient groups by targeting nuclear receptors (NRs). This NR group is a family of 48 related receptor proteins with important roles in cellular decision-making. Amongst these NRs several have been traditional targets for successful medicinal developments. In light of new developments in the NR field, PML sees the opportunity to continue with drug discovery in this area in the context of personalised medicine. PML has established a fully equipped drug discovery lab and supporting facilities at the Pivot Park in Oss, the Netherlands, where a set of unique nuclear receptor profiling assays (NAPing) on a Lab-on-a-Chip platform were developed. NAPing enables the identification of drug molecule activity on recombinant NRs, full-length NRs and homo- and heterodimerisation of nuclear receptors. PML’s discovery programmes include compound discovery from Local Traditional Medicine sources as well as repurposing and repositioning of compounds for new disease indications. To assure access to a solid understanding of the latest technology insights and market developments in disease fields of interest, PML projects are performed in collaboration with other companies, academic institutions and hospitals.