Project Manager, Thrive Perc Program

The Pediatric Epilepsies & Rare CNS (PERC) Gene Editing Platform is the Center for Therapeutic Genetics (CTG) project funded by ARPA-H’s THRIVE program. PERC aims to develop and clinically deploy platformized delivery of precision gene editors to treat children with developmental and epileptic encephalopathies (DEEs), including Alternating Hemiplegia of Childhood and Dravet syndrome.

CTG at the Broad Institute serves as the coordinator hub for PERC, responsible for program leadership, regulatory strategy, centralized data management, IP stewardship, and other key administrative and operational tasks. The program spans IND-enabling nonclinical studies, CMC development with CDMO partners, clinical trial execution, and regulatory strategy targeting first-in-human dosing in less than 2 years.

The ARPA-H THRIVE PERC Project Manager will own end-to-end operational coordination across a complex, multi-institutional team that includes the Broad Institute, the Jackson Laboratory, Boston Children’s Hospital, Children’s Hospital of Colorado, various patient advocacy organizations, and several biotech and industry partners.

The PM will be responsible for ensuring program advancement on timeline against ARPA-H’s defined objectives, metrics, and module payment milestones, and will serve as the operation backbone connecting nonclinical, CMC, clinical, and regulatory workstreams. This position reports to the PERC Program Director (Winston Yan, CTG Senior Director) and works in close coordination with the Center for Therapeutic Genetics Leadership and the PERC scientific and clinical teams.

The role is based in Cambridge, MA, allowing for occasional remote work.

RESPONSIBILITIES

Project Management & Coordination In addition to the PERC Program Director, serve as the primary point of contact between the PERC team and the ARPA-H THRIVE Program Manager, Contracts Officer, and associated government personnel. Maintain and manage the integrated program Gantt charge across all modules (Mod. 1 nonclinical D&D, Mod.

2 investigational medicine, Mod. 3 pilot and scale), ensuring cross-workstream dependencies are tracked and risks are surfaced early. Convene and facilitate regular internal team meetings across Broad, clinical sites, CDMOs, and patient organization partners; prepare agendas, drive decisions, and track action items to closure.

Coordinate data sharing, technology transfer, and communication protocols among all team members per THRIVE’s Performer Agreement requirements. Organize and manage all ARPA-H required reporting, including monthly technical and financial status reports, quarterly reviews, and end-of-module reports; ensure submissions are on time, accurate, and tell a coherent narrative of progress.

The expected base pay range for this position as listed above is based on a 40 hour per week schedule. Broad provides pay ranges representing its reasonable and good faith estimate of what the organization reasonably expects to pay for a position at the time of posting. Actual compensation will vary based on factors including but not limited to, relevant skills, experience, education, qualifications, and other factors permissible by law.