Associate Medical Director

About C4 Therapeutics: C4 Therapeutics (C4T) (Nasdaq: CCCC) is a clinical-stage biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of medicines that transforms patients’ lives. C4T is progressing targeted oncology programs through clinical studies and leveraging its TORPEDO® platform to efficiently design and optimize small-molecule medicines to address difficult-to-treat diseases.

C4T’s degrader medicines are designed to harness the body’s natural protein recycling system to rapidly degrade disease-causing proteins, offering the potential to overcome drug resistance, drug undruggable targets and improve patient outcomes. For more information, please visit www.c4therapeutics.com .

Job Summary

As an Associate Medical Director, you will guide and support clinical programs, bringing together your medical expertise, collaborative mindset, and ability to inspire cross-functional teams. You will support the clinical development plan for new compounds, and clinical studies, and partner with Program Teams across Research & Development to map the path toward regulatory approval.

You’ll work closely with colleagues across all phases of development, lead discussions with academic study investigators, engage with opinion leaders, and engage with Health Authorities on behalf of C4T. A genuine passion for advancing science, a talent for uniting diverse perspectives, and a shared commitment to improving the lives of patients with cancer will be key to success in this role.

Your Role

Drive development programs, collaborating with Program Management, Clinical Operations, Regulatory Affairs, and cross-functional teams, collaboratively refining oncology clinical study protocols from first-in-human Phase I through pivotal studies supporting regulatory submissions. Collaborate with cross-functional teams, including clinical operations, regulatory affairs, and biostatistics, to ensure alignment on clinical strategy and study design.

Serve as the medical monitor for assigned clinical trials in relapsed refractory multiple myeloma, providing ongoing medical oversight and guidance, addressing any issues that arise, including those related to protocol conduct and/or individual subject safety to ensure timely completion and high-quality data. Guide decision-making on recruitment, study conduct and on dose escalation and early clinical signals of activity if appropriate to trial stage.

Assesses overall safety information for studies and compound in conjunction with Pharmacovigilance. Develop and maintain strong relationships with key opinion leaders, investigators, and clinical trial sites. In collaboration with C4T’s Senior Medical Director, provide input in preparing global regulatory filings, including clinical sections of Investigator’s Brochures (IBs), Investigational New Drug (IND) applications, Clinical Trial Applications (CTAs), and New Drug Applications (NDAs).

Facilitate regular engagement with academic clinical investigators, support site initiation visits, and lead investigator meetings in a way that fosters collaboration, trust, and shared learning. Assist Pharmacovigilance in reviewing and interpreting clinical data, ensuring accuracy, context, and patient safety. Serve as a representative of C4T with the scientific community, contribute to publication plans, and build relationships with external experts to inform program strategies.

Your Background Required: A M.D., or internationally recognized equivalent, with at least one year of clinical research experience within the pharmaceutical industry, at a CRO or health-related consulting company, or within academia. A flexible contributor who can balance strategic vision with hands-on execution and work both collaboratively in a fast-paced, team-based matrix environment and to function independently as appropriate.

Exceptional scientific communication skills who listens actively, adapts to diverse audiences, and builds understanding across teams and stakeholders. Superior interpersonal and negotiating skills with the ability to proactively predict issues and solve problems and drive decision-making within a multi-disciplinary, multi-regional, matrix teams by leveraging diplomacy and positive influencing abilities.

Strong analytical and problem-solving skills with keen attention to detail. Preferred: Clinical Development experience in biotechnology or pharmaceutical settings, including experience with companion diagnostics, clinical operations, and pharmacovigilance. Experience with oncology and/or hematology, either in practice or in a life sciences setting Compensation The base pay range for this position at commencement of employment is expected to be between $230,938.

00 and $255,245.00 annually; however, base pay offered may vary depending on multiple individualized factors, including job-related knowledge, skills, and experience. C4 Therapeutics is an Equal Opportunity Employer.