Head of Commercial

About Boltz Boltz is a public benefit company building the next generation of AI-powered molecular modeling tools to make biology programmable and accelerate drug discovery, while keeping frontier capabilities broadly accessible. Boltz-1, Boltz-2, and BoltzGen are open models trusted by 100,000+ scientists across biotech and academia, and used in programs at every Top 20 pharma as well as leading agrichemical and industrial research organizations. We deliver these capabilities through Boltz Lab, our platform for running our latest models and design agents as reliable, production-grade tools. Boltz Lab is designed around real chemistry and biology workflows, so teams can start from a target and a hypothesis and quickly generate, evaluate, and rank candidate molecules.

About the role

As Head of Commercial, you will own Boltz’s enterprise commercial motion, converting inbound interest from leading pharma and biotech organizations into large, structured platform partnerships. Boltz already has a strong top-of-funnel driven by scientific credibility and open-source adoption.

Your role

is to translate that demand into $1M+ ACV enterprise contracts, deploying Boltz models into secure customer environments and structuring long-term collaborations. You will operate as a player-coach: personally leading high-value deals while building a repeatable enterprise sales motion. This includes scoping complex engagements, negotiating contracts, and expanding key accounts over time. You will work closely with the CEO, scientific leadership, and product to ensure that commercial engagements are grounded in real scientific value and aligned with Boltz’s long-term platform vision.

About you

5+ years of experience in sales or business development with a proven track record closing multimillion dollar enterprise deals in frontier technology (ideally software)  Comfortable leading sales and building sales function from scratch Strong technical fluency - able to engage credibly with ML, infrastructure, and product teams Ability to convert warm inbound demand into structured, closed deals without heavy SDR support Excellent communication, negotiation, and stakeholder management skills

Nice to have

Experience in life sciences, biotech, or pharma Background at companies deploying AI tools into enterprises Existing network across large pharma and biotech organizations Experience deploying products into secure or VPC environments

What we offer

Opportunity to define the commercial strategy of a category-defining AI platform Direct ownership of high-value enterprise relationships across global pharma Significant autonomy and influence at company level Highly competitive compensation with substantial equity