Senior Research Scientist - Exosome Process Development

Role Overview We are seeking a hands-on Senior Research Scientist to lead laboratory development of mammalian cell-culture and extracellular-vesicle (EV) production and purification methods. The position includes analytical characterization, process optimization, scale-up and technology transfer within Pandorum’s Cellular Engineering team.

Required Qualification Ph.D. in Biotechnology, Cell Biology, Molecular Biology, Biochemistry, Bioengineering, Regenerative Medicine, Stem Cell Biology, Pharmacology, Neuroscience or a related life-science discipline. 3- 6yrs. of relevant experience is a must Key Responsibilities Perform biochemical, molecular and cell-based assays; analyze results and maintain complete laboratory records.

Design controlled experiments with predefined objectives, appropriate comparators and biological replication; retain complete records and critically assess all findings. Develop and optimize mammalian cell-culture and upstream production processes, evaluating product yield, quality, consistency and biological activity.

Develop EV harvest, concentration and purification workflows; investigate recovery, purity and stability while preserving functional activity. Apply cell-culture and molecular-biology techniques to laboratory development studies, using suitable analytical and cell-based assays. Use structured experimental design to identify critical process variables, resolve variability and assess product comparability across development batches.

Support formulation, storage and scale-up studies; prepare technical transfer packages and work with internal teams and external partners on implementation. Contribute to process and assay documentation supporting quality, manufacturing and regulatory activities appropriate to the development stage. Own experimental plans and milestones, maintain SOPs and technical reports, communicate findings clearly and mentor junior team members.

Preferred Experience Direct experience in EV biology, EV production, engineering or characterization. Strong hands-on mammalian cell-culture, cell-biology and molecular-biology skills, with evidence of independent experimental design, troubleshooting and quantitative data interpretation. Ability to perform and interpret biochemical or molecular characterization alongside quantitative cell-based assays, with clear documentation and scientific communication.

Demonstrated hands-on process-development experience with cell-derived EVs or related biologics, including production, purification and analytical characterization. Experience in molecular biology, gene expression or biomolecular characterization, with practical competence in relevant analytical methods. Evidence of improving process reproducibility and resolving experimental or analytical variability through controlled investigation.

E xperience with tangential-flow filtration, chromatography, ultracentrifugation or other biological purification methods. Experience with nanoparticle tracking analysis, immunoassays, qPCR/RT-qPCR, RNA/protein analysis or complementary characterization methods. Experience with design of experiments, formulation, stability, scale-up, technology transfer or GMP environments; collaboration with CDMOs, CROs or analytical laboratories .