Postdoctoral Fellow-MSH-30035-400

Salary: $74,692 Department: Neuroscience Physical work location: 1415 Madison Avenue, 10-20A, New York, NY 10029 Name PI or Supervisor: Daniel Almeida da Silva e Silva, 212 659 1692, daniel.dasilva@mssm.edu Web link to Lab: dasilvalab.org Web link to Department: https://icahn.mssm.edu/about/departments-offices/neuroscience Administrative Contact: 212 659 1692 , daniel.

dasilva@mssm.edu Details of Research Project: We will investigate the role of Sirt7 , a histone deacetylase, in D1-type medium spiny neurons (D1-MSNs), focusing on how it shapes synaptic plasticity and modulates resilience to compulsive alcohol drinking. Our central hypothesis is that that epigenetic changes in D1-MSNs of the dorsomedial striatum, driven primarily by histone acetylation and modulated by Sirt7 , promote transcriptional and synaptic adaptations that jointly confer resilience to compulsive-like drinking.

The rationale for this project is grounded in compelling preliminary data suggesting that transcriptional changes in the histone acetylation process, particularly those regulated by Sirt7 , are associated with reduced compulsive-like drinking in mice through the transcriptional control of synaptic pathways. Technical Duties: (include any protocols) Responsibilities will include conducting alcohol-related behavioral experiments, including operant self-administration and other drinking paradigms; maintaining and managing mouse colonies; performing stereotaxic surgeries and related experimental procedures; monitoring animals throughout behavioral studies; and collecting brain tissue for downstream molecular and cellular analyses.

Educational and other Requirements for the position: PhD in Biological Science Experience Required: At least 5 years of experience working with laboratory mice, including mouse handling and behavioral experiments. Goals/Outcomes of the Research Project: Identify mechanisms that promote resilience to compulsive alcohol drinking, a clinically relevant phenotype of AUD characterized by continued drinking despite adverse consequences.

Compensation

Statement The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $74,692.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need.

The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 867

• Neurosciences
• ISM, Icahn School of Medicine