Meridial – Scientist – In Vivo Neurophysiology

About Meridial Meridial is a Focused Research Organisation (FRO) with a mission to bring connectomics into the living brain. We are building a platform for longitudinal, synapse-resolution mapping of functional neural circuitry in preclinical models. Our aim is to deploy this platform for translational projects and improve drug development outcomes for disorders of the central nervous system.

Meridial is a new not-for-profit FRO in the Convergent Research Ecosystem and funded by the Advanced Research and Invention Agency (ARIA).

About the role

Meridial is seeking an experienced experimental neuroscientist to join our team as Scientist – In Vivo Neurophysiology. This is a hands-on scientific role focused on developing and performing advanced in vivo experiments in mice that combine intracellular electrophysiology, two-photon imaging and optogenetic stimulation.

You will develop new approaches as part of Meridial’s programme to create advanced 3D imaging and photostimulation technologies for functional mapping of neural circuits. Your initial focus will be to establish electrophysiological ground-truth measurements for Meridial’s optical approaches to mapping functional neural connectivity.

You will combine targeted intracellular recordings with optical imaging and stimulation to understand how synaptic activity and neuronal spiking are reflected in fluorescence signals. Your results will help guide experimental strategy and serve as a crucial foundation for interpreting our optical data. You will also contribute more broadly to Meridial’s experimental programme.

That will include performing longitudinal two-photon imaging and optogenetic experiments and developing new approaches that extend the capabilities of our platform. We are looking for an exceptional experimentalist who combines strong electrophysiological and imaging expertise with scientific independence. You will join a growing Experimental Team and report to the Director of Experimental Research.

You will work closely with engineers and computational researchers across Meridial and help train and mentor experimental team members.